Physiological function[ edit ] Until the late s, hyaluronic acid was described as a " goo " molecule, a ubiquitous carbohydrate polymer that is part of the extracellular matrix. Along with lubricin , it is one of the fluid's main lubricating components. Hyaluronic acid is an important component of articular cartilage , where it is present as a coat around each cell chondrocyte.
When aggrecan monomers bind to hyaluronan in the presence of HAPLN1 hyaluronanic acid and proteoglycan link protein 1 , large, highly negatively charged aggregates form.
Future treatment of osteoarthritis. Orthopedics ;28 2 Suppl: Holmes and et al. Hyaluronic acid in human articular cartilage:
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- The most effective types have more than one size of hyaluronic acid molecules, since various sizes work in different ways.
- Hyaluronan's contribution to tumor growth may be due to its interaction with CD
- When skin is exposed to excessive UVB rays , it becomes inflamed sunburn and the cells in the dermis stop producing as much hyaluronan, and increase the rate of its degradation.
- It not only can promote the inflammation, as stated above, but also can moderate the inflammatory response, which may contribute to the stabilization of granulation tissue matrix, as described in the following part.
- The catabolic fate of hyaluronic acid.
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